Thermodynamics of 3-hydroxy-7-bromo-5-(2'-chloro) phenyl-1,2-dihydro-3h-1,4-benzodiazepine-2-ones esters complexation with the central benzodiazepine receptors
The complexation of 3-alkylcarbonyloxy-7-dihydro-3Н-1,4-benzodiazepine with the central benzodiazepine receptors at six temperatures. The ester carbonyl groups in compounds 1 and 2 are also supposed to form different hydrogen bonds with the receptor.
Подобные документы
Testing scheme of the synthesis of ester atsalamov acids and subsequent cyclization of the intermediate 3-hydrazinopyridazine-2-ones with carbonyl-containing compounds to provide chemical diversity of the final products containing a practical substitute.
статья, добавлен 20.03.2016Features complexation of adsorption of calixarene hydroxymethylphosphonic acid on the hypersil CN surface. Implementation the molecular modelling of calixarene hydroxymethylphosphonic acid and its complexes with tryptophan and N-acetyltryptophan amide.
статья, добавлен 20.03.2016The formation of the potassium salt of 3-substituted 6-thio-6,7-dihydro-2H-[1,2,4]triazino[2,3-C]quinazoline-2-ones in the presence of potassium hydroxide in alcohols via reaction of 6-R-3-(2-aminophenyl)-1,2,4-triazin-5-ones (2) with carbon disulfide.
статья, добавлен 22.02.2014To study the activity of functional groups of polyurethanes, the characteristics of the stabilization process, the formation of silver nanoparticles. The use of antimicrobial polymeric materials. The interaction of hydrogen bonds between groups of biuret.
статья, добавлен 30.07.2016The way to save part of the energy released when hydrogen bonds are formed in the form of the energy intensity of their mesh. Conditions for the onset of synchronous transitions of protons from single molecules to molecules of the H-bond network.
статья, добавлен 10.05.2018The transformation of 4-oxo-3,4-dihydroquinazolinone derivatives containing an ester group under the conditions of the Grignard reaction. Investigated acetic acid esters proceeds involving the ester group and the excess. The studying reaction of reagent.
статья, добавлен 01.03.2014History of the nucleophilic substitution of hydrogen in aromatic compounds, obtaining picric acid. Survey of SNH Substitution. Heterocyclizations Based on SNH Reactions. Intramolecular One-Step SNH Cyclizations; cascade Sequences Based on SNH Reactions.
научная работа, добавлен 05.03.2013The chemical bonds formed by the interaction of electrons. Compound atoms in the molecule. Filled valence shell. The orbital space around the nucleus. The relationship between hydrogen atoms. Interaction of alkali or alkaline earth metals with halogens.
презентация, добавлен 22.02.2015Chemical properties of organic compounds derived from ammonia. The mechanism of substitution of hydrogen for hydrocarbon radicals within molecules. Classification of the most common amines. Familiarization with the formula for the secondary amine.
презентация, добавлен 06.12.2016Properties, combustion, electron energy levels. Elemental molecular forms. Covalent, organic compounds. Hydrides, protons, acids, isotopes. Discovery and use. Role in quantum theory. Natural occurrence, production: laboratory, industrial, thermochemical.
реферат, добавлен 13.11.2009Synthesis semizwitterionic viologens for the crystal engineering of functional materials. Application of the control positions of molecules in crystals using hydrogen bonds. The triple helices had obtained by tunig the spacer between donor and acceptor.
статья, добавлен 17.02.2014Oxidized with solution of hydrogen peroxide multiwalled carbon nanotubes (MWCNTs) were modified with 2-hydroxyethylmethacrylate (HEMA) or chitosan (CTS). Morphology and surface properties of the pristine and modified MWCNTs have been investigated.
статья, добавлен 03.04.2014Study of kinetics of alkaline hydrolysis reaction of methyl esters of substituted 4,5-dimethoxy-N-phenyl-Anthranilic acids in binary solvent dioxane – water, analysis of the dependence lgkT from the nature and position of substituents in pantranco.
статья, добавлен 29.01.20163-Bromo and 3-chloro-3-trifluoroacetyl-1-methyl-2-pyrrolidinones by the halogenation reaction of the corresponding 3-trifluoroacetyl derivatives. Characteristic hydrates after simple filtration on silica gel. The formation of new spirocyclic lactams.
статья, добавлен 14.02.2014Mecamylamine - a nonselective antagonist of nicotinic acetylcholine receptors that was developed as an antihypertensive medication. Application of mecamylamine - one of the processes that decreased inter-event intervals between continuous discharges.
статья, добавлен 11.05.2022Carbon as the element essential to all of life, and hence the basis for a vast field of study. Electronegativity value of fluorine. Plastic polystyrene - important product of the hydrocarbon family. Chemical properties of carboxylic acids and esters.
доклад, добавлен 15.09.2014Reactions of Thiocyanate and Isothiocyanate Derivatives of Fluoroolefins with N-Nucleophilic Reagents. The Influence of the N-Nucleophile on the Construction of Six-Membered Heterocycles. The Use of Fluoroolefins with a Carbonyl-Containing Substitutent.
статья, добавлен 05.03.2013Treating the properties of oxidized activated carbon KAU by different temperatures in inert atmosphere were studied by means of DTA, Boehm titration, XPS and AFM methods and their catalytic activity in hydrogen sulphide oxidation was established.
статья, добавлен 04.04.2014Characteristic of features of rechargeable nickel-metal hydride batteries, which predominantly used in hybrid electric vehicles. Acquaintance with crystallographic data nickel-metal hydride. Analysis of thermodynamics and kinetics of the interactions.
статья, добавлен 23.02.2017Substituent tautomerism of six-membered ring heterocycles. Compounds with one, two or more potentially tautomeric functional group. The prototropic tautomerism of hydroxypyridine is a prototype for oxo-hydroxy tautomerization processes in heterocycles.
статья, добавлен 05.03.2013- 21. Copper(II) and nickel(II) with N-bis(salicylidene)thiosemicarbazide heterometal complex compounds
Heterometal coordination compounds of copper(II), nickel(II), alkaline-earth metals with N-bis(salicylidene)thiosemicarbazide have been synthesized. Using elemental analysis has been shown that the synthesized compounds have semi-conducting properties.
статья, добавлен 30.08.2016 Organometallic complexes of Non-Transition Metals with Scandium, Titanium, and Vanadium Group Metals, with Chromium Group Metals, with Three, Two and One Carbonyl Groups. Meaning of polypyridine ligands, especially the formation rhenium and ruthenium.
научная работа, добавлен 05.03.2013The study of the synthesis and physicochemical properties of derivatives of 4-phenyl-5-(1,2,3-benzotriazolyl 1)-3-merkapto-1,2,4-triazole(4H). Due to computer prognosis data the substances synthesized are prospective anticonvulsants and antiasthmatics.
статья, добавлен 05.03.2014The method of synthesis of fluorinated heterocycles. The use of mono- and 1,3-dicarbonyl substrates and their nitrogen-containing analogues. Biological activity, physical and chemical properties of heterocyclic compounds with perfluoroalkyl groups.
научная работа, добавлен 05.03.2013Study crystallographic sequence of the phase transition in zirconium dioxide at heated. The transformation of monoclinic phase in tetragonal modification. The appearance of new anion vacancies, which form at evaporation of the oxygen from the lattice.
статья, добавлен 30.07.2016