The efficient synthesis of 3-R-6-thio-6,7-dihydro-2H-[1?2?4]triazino[2,3-c]-quinazoline-2-ones and their derivatives, antimicrobial and antifungal activity
The formation of the potassium salt of 3-substituted 6-thio-6,7-dihydro-2H-[1,2,4]triazino[2,3-C]quinazoline-2-ones in the presence of potassium hydroxide in alcohols via reaction of 6-R-3-(2-aminophenyl)-1,2,4-triazin-5-ones (2) with carbon disulfide.
Подобные документы
Influence of increasing the temperature of thermochemical activation of up to 750 °C and increasing the dosage of potassium hydroxide to 2.1 g/g of activated carbon synthesis of hydrolytic lignin on the formation of adsorption properties of the AC.
статья, добавлен 30.07.2017Prepared of n-aryl-2-[(4-amino-4H-1,2,4-triazol-3yl)thio] acetamides by interaction of amino-1,2,4-triazolyl-3thiol with n-aril-2-chloroacetamides and formation of n-aryl-2-[6,8-dimethyl[1,2,4]triazolo[4,3-b]pyradazin-3-yl)thio]acetamide derivatives.
статья, добавлен 18.02.2014Investigation of the influence of electronic effects of substitution of maleic anhydride with hydrazine in acetic acid. Determination of CO stretching vibrations in the middle of the strip plane strain. Characteristics of magnetic shifts quinazolines.
статья, добавлен 17.02.2014The basic properties of alkoxides. Production technology of alkali metals alkoxides. Direct Synthesis in the Interaction of Metal and Alcohol. Interaction Metals Oxides and Hydroxides with Alcohols. Exchange reactions with alcohols, transesterification.
статья, добавлен 28.07.2017History of the free element. Isotopes, properties: physical, chemical. Potassium cations in the body. Biochemical function, membrane polarization. Filtration, excretion, potassium in the diet and by supplement. Applications: biological, food, industrial.
реферат, добавлен 13.11.2009The efficient synthetic protocol for aminomethylation proceeding was developed which led to obtaining a series of novel 3-(phenylamino)-methyl derivatives of 5,7-dimethyl-6-phenylazo-3Н-thiazolopyridin-2-one. The conditions for aminomethylation reaction.
статья, добавлен 30.08.2016Thiophene derivatives, cyclopropenethiones, dithiynes, carbon disulfide in the synthesis of thienothiophenes and their analogues. Reactivity and chemical transformations. Molecular structures and physical properties fields of application thienothiophenes.
дипломная работа, добавлен 05.03.2013Physical and chemical properties of the drugs. Reactions to chloride ions Cl- in a solution of AgNO3 in HNO3. Photocolorimetry with painted ferum hydroxamate. Reaction on heterocyclic atom of nitrogen. Using of methods of quantitative determination.
презентация, добавлен 24.11.2016Method of syntesis of novel N-substituted 3-(aminosulfonyl)-2H-1-benzopyran-2-one in the Knoevenagel condensation conditions. Studing the biological activity of derivatives against protozoan and helminth parasites, active against Onchocerca lienalis.
статья, добавлен 19.02.2014The study of the synthesis and physicochemical properties of derivatives of 4-phenyl-5-(1,2,3-benzotriazolyl 1)-3-merkapto-1,2,4-triazole(4H). Due to computer prognosis data the substances synthesized are prospective anticonvulsants and antiasthmatics.
статья, добавлен 05.03.2014- 11. Enhancement of the hydrogen sorption on mesoporous carbon by doping with palladium nanoparticles
Using the matrix synthesis protocol of Ryoo for the preparation of highly ordered cubic mesoporous carbon using mesoporous silica as a template, in order to prepare palladium-doped. Analyzes formation of mesoporous carbon followed by X-ray diffraction.
статья, добавлен 02.04.2014 3-Bromo and 3-chloro-3-trifluoroacetyl-1-methyl-2-pyrrolidinones by the halogenation reaction of the corresponding 3-trifluoroacetyl derivatives. Characteristic hydrates after simple filtration on silica gel. The formation of new spirocyclic lactams.
статья, добавлен 14.02.2014The complexation of 3-alkylcarbonyloxy-7-dihydro-3Н-1,4-benzodiazepine with the central benzodiazepine receptors at six temperatures. The ester carbonyl groups in compounds 1 and 2 are also supposed to form different hydrogen bonds with the receptor.
статья, добавлен 05.03.2014Influence of synthesis conditions on ceria particles size. Anticorrosion properties of modified carbon nanotubes. Realization the synthesis in aqueous solution at room temperature that reduces the cost of the preparation procedure of nanosized ceria.
статья, добавлен 04.04.2014- 15. A synthetic approach of d-glucose derivatives: spectral characterization and antimicrobial studies
Synthesis of new series of derivatives of methyl 4, 6-o-(4-methoxybenzylidene)-b-D-glucopyranoside direct acylation with a wide range of acylating agents. Spectral and elemental analysis data of antibacterial action of the synthesized compounds.
статья, добавлен 23.02.2016 Application of the SwissADME web tool for the analysis of pharmacokinetics and properties of medicines. Study of antimicrobial activity and toxicity of phenylquinazoline derivatives, Assessment of metabolism, determination of solubility of compounds.
статья, добавлен 03.09.2024Determination of biological activity of newly synthesized physiologically active substances. Study of antimicrobial activity, inhibits the development of gram-positive and gram-negative microorganisms. The features of systematic studies of 4-ticinonline.
статья, добавлен 28.01.2017The transformation of 4-oxo-3,4-dihydroquinazolinone derivatives containing an ester group under the conditions of the Grignard reaction. Investigated acetic acid esters proceeds involving the ester group and the excess. The studying reaction of reagent.
статья, добавлен 01.03.2014Study of the synthesis of complexes of diacetylhydrazine with hydrazine hydrate. Carrying out the reaction of the ligand with cobalt in the presence of salts of metal chloride and furfural. Condensation of diacetylhydrazine with hydrazine monohydrate.
статья, добавлен 15.01.2021Using phosphoric acid and phosphor pent oxide as new catalyst for preparing of derivatives of benzoxazole. Use of benzoaxol ring in medicinal chemistry. Synthesis of 1,3-(Benzene-1,3-diyl) bis(benzoxazole). Synthesis of 3-(2-Hydroxynaphthol) benzoxazole.
статья, добавлен 21.01.2021Study the interaction of an order of amino-anthraquinones with benzoylisothiocyanate. The process of obtaining the formation of new N-benzoyl-N '- (9,10-dioxo-9,10-dihydroanthacen-1- yl) -thioureas. Quantumchemical analysis of the passing reaction.
статья, добавлен 23.02.2016Study of kinetics of alkaline hydrolysis reaction of methyl esters of substituted 4,5-dimethoxy-N-phenyl-Anthranilic acids in binary solvent dioxane – water, analysis of the dependence lgkT from the nature and position of substituents in pantranco.
статья, добавлен 29.01.2016Synthesis of a polymer by the reaction between maleic acid and 2-methylquinoxaline 1,4-dioxide. Using photocatalysis during synthesis. The reaction of the polymer with maleic acid molecules. Determination of the reaction mechanism and polymer structure.
статья, добавлен 03.11.2020The specificity of the hydrothermal method for the synthesis of calcium carbonate. Determination of the nanostructure in the present inorganic chemical compound of salt carbonic acid and calcium. The diffraction characteristics of the calcium salt.
статья, добавлен 30.07.2016The one-step procedure of simultaneous preparation of polyacrylonitrile-based carbon support and Fe-Pd bimetallic nanoparticles. The effect of synthesis conditions on the metal-carbon nanocomposite structural characteristics. The crystallite size.
статья, добавлен 27.08.2020