Syntesis of novel N-substituted 3-(aminosulfonyl)-2H-1-benzopyran-2-one derivatives and their biological activity
Method of syntesis of novel N-substituted 3-(aminosulfonyl)-2H-1-benzopyran-2-one in the Knoevenagel condensation conditions. Studing the biological activity of derivatives against protozoan and helminth parasites, active against Onchocerca lienalis.
Подобные документы
Drugs based on the 1,2,4-triazole have a wide spectrum of biological activities. They are effective cardioprotectors, hepatoprotectors, anti-oxidants. Compounds with strong diuretic activity have been found among the newly synthesized compounds.
статья, добавлен 13.01.2017The formation of the potassium salt of 3-substituted 6-thio-6,7-dihydro-2H-[1,2,4]triazino[2,3-C]quinazoline-2-ones in the presence of potassium hydroxide in alcohols via reaction of 6-R-3-(2-aminophenyl)-1,2,4-triazin-5-ones (2) with carbon disulfide.
статья, добавлен 22.02.2014The study of the synthesis and physicochemical properties of derivatives of 4-phenyl-5-(1,2,3-benzotriazolyl 1)-3-merkapto-1,2,4-triazole(4H). Due to computer prognosis data the substances synthesized are prospective anticonvulsants and antiasthmatics.
статья, добавлен 05.03.2014Convenient method of synthesis of optically active oxamoylaminoacids. Compounds have significant hepatoprotective, antiinflammatory and immunodepressant activities with low toxicity. Influence of investigated sudstances on rarametrs of specific immunity.
статья, добавлен 15.02.2014Study of kinetics of alkaline hydrolysis reaction of methyl esters of substituted 4,5-dimethoxy-N-phenyl-Anthranilic acids in binary solvent dioxane – water, analysis of the dependence lgkT from the nature and position of substituents in pantranco.
статья, добавлен 29.01.2016Alkylation of potassium 9-R1-10-R2-3-R-2-oxo-2Н-[1,2,4]triazino[2,3-с]quinazolin-6-thiolates by N-cycloalkyl-(cycloalkylaryl-)-2-chloracetamides. Analizes of indicators of the antiviral activity of compounds 3.2 and 3.14 against influenza type A H3N2.
статья, добавлен 29.01.2016The efficient synthetic protocol for aminomethylation proceeding was developed which led to obtaining a series of novel 3-(phenylamino)-methyl derivatives of 5,7-dimethyl-6-phenylazo-3Н-thiazolopyridin-2-one. The conditions for aminomethylation reaction.
статья, добавлен 30.08.2016The method of synthesis of fluorinated heterocycles. The use of mono- and 1,3-dicarbonyl substrates and their nitrogen-containing analogues. Biological activity, physical and chemical properties of heterocyclic compounds with perfluoroalkyl groups.
научная работа, добавлен 05.03.2013Thiophene ring closure in pyridine derivatives. Syntheses of tri- and polycyclic systems based on thienopyridines. Pyridine ring closure in thiophene derivatives. Methods for the preparation of thieno[3,2-b]pyridine derivatives and their properties.
статья, добавлен 05.03.2013The transformation of 4-oxo-3,4-dihydroquinazolinone derivatives containing an ester group under the conditions of the Grignard reaction. Investigated acetic acid esters proceeds involving the ester group and the excess. The studying reaction of reagent.
статья, добавлен 01.03.2014Synthesis of folate-ferrocene conjugate (FFC) through a stage of synthesis ferrocene carboxylic acid. Confirmation of the structure of the conjugate by the methods of spectroscopy. Studies of the biological activity of FFC by the method of tissue culture.
статья, добавлен 21.12.2016- 12. A synthetic approach of d-glucose derivatives: spectral characterization and antimicrobial studies
Synthesis of new series of derivatives of methyl 4, 6-o-(4-methoxybenzylidene)-b-D-glucopyranoside direct acylation with a wide range of acylating agents. Spectral and elemental analysis data of antibacterial action of the synthesized compounds.
статья, добавлен 23.02.2016 Application of the SwissADME web tool for the analysis of pharmacokinetics and properties of medicines. Study of antimicrobial activity and toxicity of phenylquinazoline derivatives, Assessment of metabolism, determination of solubility of compounds.
статья, добавлен 03.09.2024Some aspects of sugar-derived heterocycles and their precursors which are utilized as the inhibitors against glycogen phosphorylases and are responsible for the release of mono-glucose from poly-glucose. The quantitative structure-activity relationship.
научная работа, добавлен 05.03.20133-Bromo and 3-chloro-3-trifluoroacetyl-1-methyl-2-pyrrolidinones by the halogenation reaction of the corresponding 3-trifluoroacetyl derivatives. Characteristic hydrates after simple filtration on silica gel. The formation of new spirocyclic lactams.
статья, добавлен 14.02.2014Using phosphoric acid and phosphor pent oxide as new catalyst for preparing of derivatives of benzoxazole. Use of benzoaxol ring in medicinal chemistry. Synthesis of 1,3-(Benzene-1,3-diyl) bis(benzoxazole). Synthesis of 3-(2-Hydroxynaphthol) benzoxazole.
статья, добавлен 21.01.2021Structure, a composition, a biological role, synthesis and catabolism of phospholipids. Conversion of Squalene to Cholesterol. Determination of interdependence of the deficiency of hydrolytic enzymes and lysosoms support sphingolipidosis development.
презентация, добавлен 05.10.2015Changes of structural and power parameters of molecules of Laevomycetinum, conditioned by adsorption. Descriptors of biological activity of Laevomycetinum are energy of НВМО and length sanctify O hydrogen - H.O in the propanediol fragment of molecule.
автореферат, добавлен 02.04.2014Preparative and research methods of biochemistry, molecular biology, and biotechnology. Application of the affinity of biological molecules to complementary structures. Consideration of using scheme for activation cascade of the blood clotting system.
статья, добавлен 15.04.2024Prepared of n-aryl-2-[(4-amino-4H-1,2,4-triazol-3yl)thio] acetamides by interaction of amino-1,2,4-triazolyl-3thiol with n-aril-2-chloroacetamides and formation of n-aryl-2-[6,8-dimethyl[1,2,4]triazolo[4,3-b]pyradazin-3-yl)thio]acetamide derivatives.
статья, добавлен 18.02.2014Chemical derivatives of 1,2,4-thiazole as biologically active chemicals intended for the protection of plants for agricultural purposes, such as biocides and fungicides when preserving books. Impact of chemicals on humans, animals and the environment.
статья, добавлен 21.07.2018Biological, physical and chemical properties of macrocyclic compounds based on the researches of membrane activity. Finding of the certain concentration of filipin for increase of conductivity, definition of selectivity and single ionic filipin channels.
статья, добавлен 22.02.2021The ultrasonic cavitation activity in aqueous solution of carbon dioxide was studied. The ICA-3M cavitometer was used for cavitation activity estimation. Erosion rate was estimated in a number of regimes. The spectra of cavitation noise were recorded.
статья, добавлен 19.02.2021Tetrahydroxycalix[4]arene, tetraalkoxycalix[4]arenes and tetraalkylcalix[4]resorcinarenes are capable to reversible adsorption on the surface of the hydrophobic support lichrosorb RP 18. Conditions reversed high-performance liquid chromatography.
статья, добавлен 28.08.2016Investigation of the influence of electronic effects of substitution of maleic anhydride with hydrazine in acetic acid. Determination of CO stretching vibrations in the middle of the strip plane strain. Characteristics of magnetic shifts quinazolines.
статья, добавлен 17.02.2014