Antimicrobial activity of [1,2,4]triazolo[4,3-а]pyrazin-8(7H)-one derivatives
The search for new and effective antimicrobial and antifungal agents is an important task of medical chemistry. The results of microbiological screening of new derivatives of [1,2,4]triazolo[4,3-a]pyrazine. Increased exposure to the microbial cell.
Подобные документы
Given the presence of antimicrobial activity for tetrazole derivatives and its condensed analogues, it was proposed to analyze 13 novel 5-phenyl-5,6-dihydrotetrazolo[1,5- c]quinazolines for molecular docking to ribosomal in comparison with Tedizolid.
статья, добавлен 02.10.2024Overexpression in many human cancers. Molecular docking of ZSTK474 derivatives as PI3Kbeta inhibitory agents. Review absorption, distribution, metabolism and excretion and possible pharmacological activity сhemical. Additional binding energy human.
статья, добавлен 30.10.2016Meaning of calcium hydroxide as intracanal medicament for antimicrobial activity. Physico-chemical properties of this substance and its efficacy for disinfecting the entire root canal system. The relationship of calcium hydroxide with medications.
статья, добавлен 29.03.2013Analysis of resistance to antimicrobial drugs of pathogens that were obtained in a private laboratory. Methods of assessing sensitivity to antimicrobial drugs of selected isolates. Strains obtained from patients of a clinic, their antibiotic resistance.
статья, добавлен 25.06.2024The study of the antimicrobial properties of tincture sophora japonica and chlorhexidine bigluconate. Methods of treatment of periodontitis, gingivitis and stomatitis. Comparative evaluation of the cost of the use of drugs "Hexoral" and "Fitodent".
статья, добавлен 29.01.2016Adaptation to eugenol and citral by exposure of pathogens to increasing concentrations of essential oils. Determination of antibiotic susceptibility. Evaluation of the effect of eugenol and citral on the adherence ability by the crystal violet assay.
статья, добавлен 15.01.2021The leather is sensitive to microbial degradation during processing, storage, transportation and use. It is important to search for preparations and methods of leather treatment, providing specific fungicidal properties, depending on the purpose.
статья, добавлен 08.09.2020Analysis of the problem of search biologically active substances among derivatives of aromatic aminoacids. Research of physical and chemical properties and structure, pharmacological activities of methyl esters of 6-nitro-N-phenylanthranilic acids.
статья, добавлен 24.02.2016Structural formula of Tedizolid as antimicrobial and structural analogue and proposed 5-phenyl-5,6-dihydrotetrazolo[1,5-c]quinazolines. Affinity to binding sites of 2QEX, with decreasing of score. Descriptives of formed bonds to 50S ribosomal protein L2P.
статья, добавлен 04.09.2024Chlorhexidine gluconate is an effective oral antimicrobial agent and is used in periodontal therapy and for caries prevention. Mean leakage trends across time for each irrigant (sealer) combination. Effect of Chlorhexidine Gluconate on the Apical Seal.
статья, добавлен 30.03.2013A modern alternative approach to antimicrobial therapy is targeting bacterial virulence and specifically adhesion as one of virulence factors. Modern strategies for anti-adhesion therapy, the mechanisms of inhibition pathogen adherence, immunization.
статья, добавлен 19.03.2016Criteria of stability antibacterial agents for children. The advantages of polyethylene terephthalate containers for the storage of cosmetics. The total list of regulatory documents stipulating technical and pharmaceutical terms savings of hygiene.
статья, добавлен 29.01.2016The various formulations of calcium hydroxide. The use of active components that have been added to calcium hydroxide, including antimicrobial and antiinflammatory agents. Determination of the p-monochlorophenol residue in the calcium hydroxide.
статья, добавлен 05.03.2013Strategy of the search and working out of novel effective anticancer agents via optimization of [(2-R-quinazoline-4-ylydene) hydrazono] carboxylic acids and their esters. Approach for creating a new class of compounds with the anticancer activity.
статья, добавлен 30.10.2016Most Enterococcus species and their habitat. A scanning electron micrograph of a dividing cell. Virulence and pathogenicity of enterococci. Modulation of the host immune response. Antimicrobial resistance of enterococci. E. faecalis and biofilm formation.
статья, добавлен 10.12.2013Pharmacological activity of the main derivatives of 1,5-benzodiazepines. Interaction of 4-phenyl- and 4-methyl-2,3-dihydro-1H-1,5-benzodiazepinones-2 with epichlorohydrin under various conditions. The use of hard and soft basic reaction systems.
статья, добавлен 30.10.2016Clinical thinking plays a significant role in training highly qualified workers, as it creates the basis for transforming knowledge into the ability to apply it in practical. For healthcare workers, the formation of professional competence is significant.
статья, добавлен 26.12.2023The role of alpha oscillations in protecting important information from distractions while performing a task on working memory. The ability to efficiently filter relevant from irrelevant information supports. Study of the activity of the cerebral cortex.
статья, добавлен 27.08.2020According to the results of toxicological screening in 1990-2020 it was found that natural opium products an important component of the spectrum of narcotic drugs that cause poisoning, and their structure has changed significantly during the study period.
статья, добавлен 25.06.2024The prevalence of noncommunicable diseases. Risk factors around the world that require a comprehensive response from the health system. Measures to combat the epidemic of noncommunicable diseases. National program of screening preventive examinations.
статья, добавлен 19.04.2018The search for new effective methods of effective therapeutic effect in order to improve the quality and increase the life expectancy of patients with coronary heart disease. A study of a polyphenols - resveratrol for the treatment of patients with CHD.
статья, добавлен 16.06.2024The increase secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline. Secretory activity of mast cells in unstressed animals. The stabilizing effect of peptides.
статья, добавлен 10.03.2014The impact of the New Rural Cooperative Medical Scheme on medical service utilization in rural China using an econometric accounting for selection and cen-soring problems in data. The results show the increases the number of outpatient visits per capita.
статья, добавлен 28.09.2016Causes of interappointment pain. Presence of pathogenic bacteria. Presence of virulent clonal types. Microbial synergism or additism. Number of microbial cells. Apical extrusion of debris. Secondary intraradicular infections. Non-microbial causes.
статья, добавлен 10.12.2013Monitored the most common physical activity performed by older adults, weekly frequency of the chosen physical activity, together with the prevalence of diseases of affluence. Consideration and characterization of medical conditions of older adults.
статья, добавлен 29.10.2020