Defining the role of gene deletion TP 53 in the diagnosis and prognosis of chronic lymphoproliferative neoplasms using the method of fluorescence in situ hybridization
The results of molecular cytogenetic studies in 60 patients with chronic lymphoproliferative neoplasms. Clonal deletions of TP 53 gene were detected in 20% of patients with CLPN: eight of 20 patients with B-cell chronic lymphocytic leukemia (B-CLL).
Подобные документы
Evaluating the prognostic value of circulating osteonectin for cumulative survival in patients with ischemic chronic heart failure. Using ELISA methods for measurements of circulating level of osteonectin. Studying increased circulating osteonectin.
статья, добавлен 14.08.2016Study of anti-remodeling effectiveness of complex pharmacotherapy to patients with chronic heart failure and metabolic syndrome using perindopril, spironolactone and bisoprolol. Anti-remodeling efficacy of the combined use of the studied drugs.
статья, добавлен 15.02.2021Metabolic syndrome as a cause of stroke risk in chronic cerebral ischemia. Determination of the features of changes in the structure of the vascular wall in patients with chronic cerebral ischemia, depending on the presence of metabolic syndrome.
статья, добавлен 19.02.2021The causes of the growing trend for complaints of gastrointestinal nature. General characteristics of functional disorders of the digestive system that trigger the subsequent development of chronic pancreatitis. Methods of treatment cholecystectomy.
статья, добавлен 20.03.2016Improved myocardial contractility. Reducing end-diastolic volume. Significant improvements in functional capacity of patients with chronic heart failure and quality of life. Transplantation of stem cells of fetal origin in treatment as effective method.
статья, добавлен 24.02.2016A retrospective analysis of the results of the treatment of patients with resectable advanced oral squamous cell carcinoma. The analysis involved the patients who have undergone primary surgery, adjuvant radiotherapy, concomitant chemoradiation therapy.
статья, добавлен 24.02.2021The results of clinical use of mTOR inhibitors, in particular, everolimus, in immunosuppressive therapy regimens. Reasons why immunosuppressive therapy regimens including mTOR inhibitors are preferred in patients with high and moderate risk of graft loss.
статья, добавлен 28.02.2016Feature research of paracrine secretion of РВМС cells in patients with chronic heart failure (CHF) under the action of isolated from the blood plasma of healthy donors exosomes in vitro. The high novelty of research in this area, relevant the investigate.
статья, добавлен 31.08.2022Correlation between clinical indicators that manifest themselves in diseases of periodontal tissues. A regular analysis the results in patients from different ecological regions of the Carpathian region during the treatment of generalized periodontitis.
статья, добавлен 26.12.2023Constant electrocardiostimulation in occasion of atrio-ventricular blockade. Forms of atrial fibrillation and syndrome of sinus node weakness with different stimulation regimens, as well as chronic heart failure with cardioresynchronizing therapy.
статья, добавлен 29.09.2016The study influence of the cardio-nephroprotective therapy on serum markers of cardiovascular risk in patients with chronic kidney disease. The possibility of practical use of FGF-23 and Klotho as an early diagnostic marker of cardiovascular risk.
статья, добавлен 19.04.2018Description of the histological changes that accompany the development of fibrosis in the pancreas. Investigation of the features of expression of proapoptotic nuclease markers and proliferation at different stages of development of chronic pancreatitis.
статья, добавлен 29.01.2017The main components of the metabolic syndrome. Determination of clinical, functional and immunological predictors of the development of pneumonia. Cytokine synthesis in response to the inflammatory process in the bronchopulmonary system of patients.
статья, добавлен 23.02.2021Evaluation of the diagnostic and prognostic value of changes in the ploidy of the chromosomal set in acute leukemias. Identification and classification of cytogenetic abnormalities in patients, their consideration when selecting optimal treatment tactics.
статья, добавлен 18.12.2023- 40. Natriuretic peptides-guided therapy in chronic heart failure: relevance to outcomes and survival
Discussion and research of specific features of the modern strategy of guided chronic heart failure therapy. Identification and characterization possible prospects for improved survival of patients through the timely correction of pharmacotherapy.
статья, добавлен 14.07.2016 The role of the sinuses in the formation of the microbiome of the respiratory tract and the presence of polyps. Proteobacteria the biological diversity of the microbiomes of the lungs and sinuses, which is associated with deterioration of lung function.
статья, добавлен 15.02.2023Investigation of the chronic heart failure and type 2 diabetes mellitus, which are closely inter-related conditions through different pathological mechanisms. Characteristic features of the platelets abnormalities according to glycemic control status.
статья, добавлен 24.02.2016Analysis of carbohydrate metabolism depending on the genotype of the leptin receptor gene (Arg223Gln) in patients with coronary heart disease and obesity. Causes of lipid metabolism disorders, hyperinsulinemia and decreased tissue sensitivity to insulin.
статья, добавлен 11.12.2023Psoriasis and its place among chronic skin diseases. Analysis and review of the main problems in the incidence of psoriasis. Information on the current status and major trends in the incidence of psoriasis in Kharkiv region. Directions care to patients.
статья, добавлен 24.02.2016The results of the study epidemiological indicators of chronic obstructive pulmonary disease: prevalence, incidence. Defining the role of tobacco in increasing the incidence of 15.4%. A study of the mortality rate for diseases of the lungs in Ukraine.
статья, добавлен 29.01.2016Description a beneficial effect of statins in abdominal aortic aneurysm. Study the gene expression of NOX4 using techniques of polymerase chain reaction with reverse transcription. Characteristics, specificity, and using the method of Western blotting.
статья, добавлен 14.07.2016Study the association of MGP gene promotor T-138C polymorphism with known risk factors of atherosclerosis. Complications illnesses in patients with ischemic stroke: hypercholesterolemia, high body mass index, diabetes, smoking, hypercoagulability.
статья, добавлен 27.03.2016Correction of redox metabolism based on the parameters of oxidative modification of proteins, the degree of their catabolic reaction and data on the lipid peroxidation in cancer patients with multiple organ resections on the gastrointestinal tract.
статья, добавлен 18.04.2022- 49. The quality of life of patients with thyroid pathology after simultaneous and isolated operations
The quality of life of patients after isolated surgical interventions - aspect of a comparative assessment. The evaluation of long-term results in patients after surgery - the indicator of the effectiveness of the method of treatment of a pathology.
статья, добавлен 27.02.2021 Diseases of the heart and blood vessels remain the main cause of mortality. This seriously affects the course of other pathological processes, - complicating diagnosis and disrupting repair processes, which reduces the effectiveness of treatment.
статья, добавлен 25.06.2024