Creating universal PSMD2 (RPN1) primers for a range of model organisms and homo sapiens
Protein degradation plays a key role in many cellular processes, degrading misfolded or abnormal proteins and thereby controlling cell proliferation, DNA repair, and stress response. Primers creating and design. Phylogenetic comparative analysis.
Подобные документы
The main stages of the recovery process integrity of bone in the case of instability of bone fragments and a significant distance between them. Factors affecting proliferation, differentiation of osteogenic cells, synthesis of extracellular matrix.
статья, добавлен 27.12.2016The pharmacological effect of the Phytocomposition №1+PhytoF on the functional state of hepatocytes, metabolism of proteins in comparison with the classical hepatoprotector Essentiale. The role of ceruloplasminin of protein metabolism in the liver.
статья, добавлен 30.04.2018The molecular nature of the new multiple forms Tks4. The formation of intracellular protein complexes. Methods of coupling affinity purification of interacting partners of cell lysates in combination with liquid chromatography tandem mass spectrometry.
статья, добавлен 27.03.2016Study the interaction of adaptor protein Ruk/CIN85 SH3 domains with endogenous indicator Tks4 in tumor cells of different tissue origins. Research of physiological responses of cell immunity in mice. New multiple molecular forms of adaptor protein.
статья, добавлен 27.03.2016The gasdermin family (GSDMs) contains a group of uncharacterized proteins that form membrane pores and serve as a major substrate for inflammatory caspases and the execution of pyroptosis, which is recognized as a novel type of programmed cell death.
статья, добавлен 03.09.2024The study of cell-mediated immunity depending on the power and time of exposure to electromagnetic radiation of radio frequency on experimental animals. Depression of cellular immunity and increase with increasing duration of the electromagnetic impact.
статья, добавлен 30.01.2016The cell death because of damage in the genome is a result of irradiation in cells. Survival in the case of intracellular repair system activation and a development of adaptation - to survive. Role of the state of prooxidant-antioxidant homeostasis.
статья, добавлен 30.01.2016Interleukin (IL)-33 is a multifunctional cytokine that belongs to the IL-1 cytokine family and expressed by multiple organs and cell types. The effect of IL-33 on proliferation of human lung fibroblasts. Ther function in lung remodeling processes.
статья, добавлен 30.10.2016Peculiarities of the course of transmissible spongiform encephalopathies depending on the patterns of protein structure formation and their interaction with cell membranes. The mechanism of formation of the pathogenic isoform of the prion protein.
статья, добавлен 20.09.2024The clinical significance of the expression of iron-containing proteins ferritin and transferrin in tumor cells of patients with breast cancer. Evaluation of the correlation dependences of the parameters of expression of these proteins in tumor cells.
статья, добавлен 29.11.2016Diseases of the heart and blood vessels remain the main cause of mortality. This seriously affects the course of other pathological processes, - complicating diagnosis and disrupting repair processes, which reduces the effectiveness of treatment.
статья, добавлен 25.06.2024Biochemical markers - component that provides information on the prognosis and course of pathology. Comparative analysis of the basic biochemical parameters that reflecting the metabolism of acute-phase proteins in a group of experimental animals.
статья, добавлен 05.06.2022Investigation of the role of metabolic disorders in the formation of disease among newborns. The study showed the clinical efficacy of the drug L-carnitine in the treatment of protein deficiency. The positive effect of "Agvantar" as metabolic therapy.
статья, добавлен 27.03.2016Stem cell types in the breast. The role of estrogen and BRCA1 gene in hereditary breast cancer. Regulation of stem cells. Analysis of the achievements predecessors embryonic, fetal and adult stem cells in the treatment of hereditary breast cancer.
статья, добавлен 29.12.2012A retrospective analysis of the results of the treatment of patients with resectable advanced oral squamous cell carcinoma. The analysis involved the patients who have undergone primary surgery, adjuvant radiotherapy, concomitant chemoradiation therapy.
статья, добавлен 24.02.2021The sensitivity of nerve function to the action of various factors: from pharmacological to environmental pollutants. Part of neurospecific proteins in the processes of learning and memory. The level of lipid peroxidation after effect of melatonin.
статья, добавлен 14.08.2016The role of glia in the pathogenesis of spinal cord injury, ischemia, neuropathic pain, and neurodegenerative diseases. Quantitative, phenotypic changes and uniqueness of the reactions of the main types of glial cells at different stages of neurotrauma.
статья, добавлен 12.04.2021Determine the effect of diacamph hydrochloride, an antihyperglycemic drug, on the cortisol content in the blood of animals with a combined model of diabetes mellitus and chronic stress. Analysis stress-protective properties of diacamph hydrochloride.
статья, добавлен 27.08.2016Modeling of disseminated intravascular coagulation syndrome with the drug "Efa-2", made on the basis of the poison of the multi-scaled snake Efa. Creating a new experimental model of DIC syndrome, which would characterize the subacute form of the latter.
статья, добавлен 05.09.2024The main functions of the human blood. The composition of blood plasma. Transportation, homeostasis, protection, hemostasis. Cells, cell fragments, and an aqueous solution of plasma. Proportion of cellular elements in total and is calleda hematocrit.
презентация, добавлен 08.12.2012Photoreceptor cGMP phosphodiesterase is an effector enzyme in the G-protein mediated visual transduction cascade. To study the mechanism of PDE6 catalytic activity inhibition by Py chimeric proteins PDE6a/PDE5 were created. The catalytic properties.
статья, добавлен 19.03.2024Evaluation of the influence on the stress distribution patterns in and the magnitude of stresses on fixed partial dentures under different anatomic and design condition. Three-dimensional finite elements models of posterior 3-unit all-ceramic FPDs.
статья, добавлен 05.03.2013The possible role of hereditary tumors in evolution. Common features of embryonic development and tumorigenesis. Non-trivial explanations of the main hypothesis and its relationships to other biological theories. Tumors and the origin of new cell types.
статья, добавлен 25.08.2020Soft tissue healing. Epithelial repair. Connective tissue repair. Role of saliva and gingival crevicular fluid in oral wound healing. Surgical site closure. Suture materials. Suture techniques and removal. Clinical review of the soft tissue healing.
статья, добавлен 10.12.2013Electrophoretic analys of globulin storage proteins in the seeds of 46 lentil accessions introduced from ICARDA was carried out. The aim of the work was to identify, certification, study the genetic diversity of lentil genotypes, genetic diversity index.
статья, добавлен 03.09.2024