Five steps of Evidence-based medicine. The first step of Evidence-based medicine. Definition of clinical problem using principle PICO
Steps in practice of evidence-based medicine. Determination problem, search of proof, evaluation of results of interference. Formulation of clinical question, its types, treatment and prevention, diagnostics, prognosis, aetiology, cost efficiency.
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Main characteristics of chelator preparations and the critical examination of the extensive literature on the their effectiveness. Clinical results on the application and the order in which the chelator should be used. The results of the dental surgery.
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