Enhancement of the base for 3,7-disubstituted [1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one derivatives as promising pharmaceutical agents
Testing scheme of the synthesis of ester atsalamov acids and subsequent cyclization of the intermediate 3-hydrazinopyridazine-2-ones with carbonyl-containing compounds to provide chemical diversity of the final products containing a practical substitute.
Подобные документы
Reviews on "Heterocyclic Compounds" on aspects such as synthesis, reactionmechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical, pharmacology, applications in material sciences.
материалы конференции, добавлен 05.03.2013Application of the SwissADME web tool for the analysis of pharmacokinetics and properties of medicines. Study of antimicrobial activity and toxicity of phenylquinazoline derivatives, Assessment of metabolism, determination of solubility of compounds.
статья, добавлен 03.09.2024The combination of a macrocyclic platform and alfa-hydroxymethylphosphonate group for the inhibition activities of compounds. Computer-simulated docking studies using AutoDock 4.2 programme by the example of PTP1B. Stereoisomeric forms of the inhibitors.
статья, добавлен 29.01.2016- 54. Copper(II) and nickel(II) with N-bis(salicylidene)thiosemicarbazide heterometal complex compounds
Heterometal coordination compounds of copper(II), nickel(II), alkaline-earth metals with N-bis(salicylidene)thiosemicarbazide have been synthesized. Using elemental analysis has been shown that the synthesized compounds have semi-conducting properties.
статья, добавлен 30.08.2016 A review on novel ring transformations of dinitropyridones and nitropyrimidinones. The synthesis of functionalized molecules, such as nitroanilines, nitropyridines by the ring transformation of dinitropyridones as the nitromalonaldehyde equivalent.
научная работа, добавлен 05.03.2013Development of a new approach to the simultaneous determination of two reducing agents, which is based on the dependence of the rate of their reaction. Automation of the method using a typical device of the method of sequential injection analysis.
статья, добавлен 30.10.2016A sample of Mg10Ir19B16, prepared from the elements by high-temperature treatment in sealed Ta containers. The chemical composition, confirmed by WDXS analysis. Electronic structure calculations and chemical bonding analysis by the ELI/ED approach.
статья, добавлен 23.02.2017Plastic additives as a wide range of chemicals used by resin manufacturers, compounds and manufacturers to improve the properties, processing and characteristics of polymers. Features of their chemical composition and conditions of effective use.
статья, добавлен 10.03.2019On the basis of experimental studies and mathematical modeling, the choice of optimal conditions for 2,3-dimethylbuta-1,3-diene and 2-hydroxyethyl methacrylate cyclization reaction with obtaining of 2-hydroxyethyl-1,3,4-trimethylcyclohex-3-carboxylates.
статья, добавлен 23.02.2016The efficient synthetic protocol for aminomethylation proceeding was developed which led to obtaining a series of novel 3-(phenylamino)-methyl derivatives of 5,7-dimethyl-6-phenylazo-3Н-thiazolopyridin-2-one. The conditions for aminomethylation reaction.
статья, добавлен 30.08.2016- 61. Algorithm of optimal solution search for the control with model system of methanol synthesis column
The mechanism of development and implementation of the optimal synthesis search algorithm and analysis of gas costs. Features of control using the maintenance schedule. Technological process of methanol synthesis under conditions close to optimal.
статья, добавлен 14.01.2017 The structural, theoretical and synthetic properties of enamines which act as important intermediates in many syntheses of organic compounds containing oxygen. Cycloaddition reactions, electrochemistry, hydrolysis and biochemistry of metalated enamines.
книга, добавлен 05.03.2013Thiophene ring closure in pyridine derivatives. Syntheses of tri- and polycyclic systems based on thienopyridines. Pyridine ring closure in thiophene derivatives. Methods for the preparation of thieno[3,2-b]pyridine derivatives and their properties.
статья, добавлен 05.03.2013Physical and chemical properties of the drugs. Reactions to chloride ions Cl- in a solution of AgNO3 in HNO3. Photocolorimetry with painted ferum hydroxamate. Reaction on heterocyclic atom of nitrogen. Using of methods of quantitative determination.
презентация, добавлен 24.11.2016Study of ternary intermetallic compounds RxMyXz (R = rareearth Element, M = d-metal, X = p-metal). Results of identification of the new R-Au-Al compound. The starting materials for the synthesis of R-Au-Ga. Function of the profile form of pseudo-Voigt.
статья, добавлен 23.02.2017Chemical compositions of Portland cement. Possibility of using waste glass in building technology. A structure alkaline compounds. Study of fine-grinded glass. Influence additives on the induction and post-induction periods of Portland cement hardening.
статья, добавлен 23.02.2016The problem of identification of paints according to the commodity nomenclature of foreign economic activity. Chemical composition are received, structures, and other organoleptic, physical and chemical parameters of production of paints and varnishes.
статья, добавлен 10.03.2018Critical reviews on "Heterocyclic Compounds" within topic-related volumes dealing with all aspects such as synthesis, reaction mechanisms, structure complexity, reactivity, stability, biology, pharmacological aspects, applications in material sciences.
учебное пособие, добавлен 05.03.2013MPWB1K/6-31+G(d) and MPWB1K/tzvp theoretical models were found to provide reasonable accuracy of the prediction of ionization potentials for mono- and polycyclic azacompounds. The root mean square errors of the methods are 0.19 and 0.20, respectively.
статья, добавлен 30.10.2016The aim of this study was to determine the quantitative and qualitative determination of fatty acids in the fruits of the plant Zosima absinthifolia, which is widespread in Absheron, as well as to study its physicochemical and organoleptic properties.
статья, добавлен 20.09.2024The development of selective oxidation of simply accessible dihydroxy-dypropoxycalix[4]arene to nitrocalixmonoquinone by mixture of 75 % nitric acid and glacial acetic acid. Synthone for design of optical sensors and redox-sensitive bio-active compounds.
статья, добавлен 11.02.2014History of the free element. Isotopes, properties: physical, chemical. Potassium cations in the body. Biochemical function, membrane polarization. Filtration, excretion, potassium in the diet and by supplement. Applications: biological, food, industrial.
реферат, добавлен 13.11.2009Physical parameter models. Thermodynamic parameter models. Brief review of the relationship between the solution model and phase equilibria. The modified quasi chemical (MQC) model. Basic quasi chemical theory. The modified binary quasi-chemical theory.
статья, добавлен 10.04.2017Synthesis of block copolymers via the polymerization of methyl methacrylate initiated by Ce4 - PEG system using a functional peroxidecontaining the services of an agent. Rheological and colloidal-chemical characteristics of new polyampholitic surfactant.
статья, добавлен 23.02.2016Influence of synthesis conditions on ceria particles size. Anticorrosion properties of modified carbon nanotubes. Realization the synthesis in aqueous solution at room temperature that reduces the cost of the preparation procedure of nanosized ceria.
статья, добавлен 04.04.2014