Molecular-biological factors of risk of recurrence and metastases development in patients with ovarian cancer of the III-IV stages
Non-adjuvant polychemotherapy - technology that indicates the presence of chemo-resistant tumor cells. Molecular-biological markers of tumors - certain chromosomal and gene mutations that involved in the development, progression of malignant diseases.
Подобные документы
Search for the main approaches to the individualization of adjuvant chemotherapeutic treatment of breast cancer. The peculiarity of the study of the effectiveness of anthracycline chemotherapy regimens for various molecular biological tumor subtypes.
статья, добавлен 23.02.2021Genetic, cellular, tissue and circulating markers in Tumors. Diseased regulatory pathways. Growth Factor-Signaling Pathways in Cancer. Antitumor immunity as therapy for human cancer. Invasion and Metastasis. Emerging molecular therapies for the disease.
книга, добавлен 05.07.2013Examination serous ovarian cancer which characterized by the most aggressive clinical course with frequent relapses in the area of small pelvis and abdomial cavity. Research and analysis of the clinical and morphological factors of ovarian cancer.
статья, добавлен 28.02.2016The possible role of hereditary tumors in evolution. Common features of embryonic development and tumorigenesis. Non-trivial explanations of the main hypothesis and its relationships to other biological theories. Tumors and the origin of new cell types.
статья, добавлен 25.08.2020Vulvar cancer is a rare malignant tumor, accounting for 3-8% of the total incidence of malignant tumors of the female reproductive system. However, in the structure of mortality, this pathology ranks fourth after cancer of the cervix, uterine body.
статья, добавлен 20.09.2021The clinical significance of the expression of iron-containing proteins ferritin and transferrin in tumor cells of patients with breast cancer. Evaluation of the correlation dependences of the parameters of expression of these proteins in tumor cells.
статья, добавлен 29.11.2016Factors determining risk of developing breast cancer, invade lymph or blood vessels-metastatic breast cancer. Invasive ductal carcinoma. Stucture of the Brea. Female breast anatomy. Development of the breast ductal tree. Occurs mainly after birth.
презентация, добавлен 03.04.2016The chromosomal anomalies, microdeletions of AZF region of Y-chromosome and CFTR gene mutations. Genetic factor of infertility and Y-chromosome AZF region microdeletions of males with spermatogenetic failure. The frequency of CFTR major mutation F508del.
статья, добавлен 24.11.2012Colorectal cancer is one of the most common oncological diseases. This problem becomes especially urgent in the case of the formation of an anemic syndrome in patients, which causes the emergence of a mutual burden syndrome and increases the risks.
статья, добавлен 18.12.2023Biomarkers of platinum resistance in patients with ovarian cancer. Relationship between survivin expression values, nitric oxide activity, glutathione-dependent enzyme expression, catecholamine content in red blood cells, and ABCA1 transporter expression.
статья, добавлен 19.09.2021The essence of stomach cancer, features, stages of development. Risk factors and a number of mutogens that cause cancer of the stomach. Symptoms of stomach cancer, features of diagnosis and ways of surgical and therapeutic treatment of its various forms.
презентация, добавлен 18.10.2017Research the role of environmental events, namely physical, chemical, biological, socio-cultural factors in the development of diseases was investigated. In particular, the lack of toxic substances in the body is a direct cause of cardiovascular disease.
статья, добавлен 04.03.2023Chemotherapy as one of the major tool in the treatment of breast cancer. The main etiology of the development of drug resistance of cancer cells to chemotherapeutic agents. Analysis of the effect of anticancer drugs on the cells of breast carcinoma.
статья, добавлен 27.03.2016The study included patients with coxarthrosis of the III-IV radiological stages, aimed at total hip arthroplasty for the period 2015-2018. Several variants of the course of the disease were identified, taking into account the age factor of the patients.
статья, добавлен 23.05.2023The results of molecular cytogenetic studies in 60 patients with chronic lymphoproliferative neoplasms. Clonal deletions of TP 53 gene were detected in 20% of patients with CLPN: eight of 20 patients with B-cell chronic lymphocytic leukemia (B-CLL).
статья, добавлен 18.12.2023Study the interaction of adaptor protein Ruk/CIN85 SH3 domains with endogenous indicator Tks4 in tumor cells of different tissue origins. Research of physiological responses of cell immunity in mice. New multiple molecular forms of adaptor protein.
статья, добавлен 27.03.2016Differentiation between "driver" and "passenger" mutation as an important task for the functionalization of cancer genomics in the treatment of patients. Differences between mutations that lead to the growth of a mutational nucleus from benign mutations.
статья, добавлен 19.02.2021Study the association of MGP gene promotor T-138C polymorphism with known risk factors of atherosclerosis. Complications illnesses in patients with ischemic stroke: hypercholesterolemia, high body mass index, diabetes, smoking, hypercoagulability.
статья, добавлен 27.03.2016Conversion chemotherapy, its application. To evaluate the outcomes of patients with B/U liver metastases from CRC treated with conversion chemotherapy with the modified fluorouracil, leucovorin, and oxaliplatin (mFLOX) regimen followed by metastasectomy.
статья, добавлен 18.02.2021Determination of the number of matrix ribonucleic acid genes in leukocytes in some forms of epilepsy and Parkinson's disease. Identification of new biomarkers of diseases for the development of molecular test systems suitable for clinical diagnosis.
статья, добавлен 19.04.2018Atherosclerosis: Signal Transduction by Oxygen and Nitrogen Radicals. Apoptotic Pathways in Cancer Progression and Treatment. Molecular and Cellular Aspects of Insulin Resistance: Implications for Diabetes. Neurotrophic Signaling in Mood Disorders.
книга, добавлен 05.07.2013Interferon - direct antitumor factor or as a part of complex cancer treatment aimed at reducing the risk of metastatic process. Analysis of the main viral vector systems used in gene therapy. Determination of the metastatic potential of MM-4 cells.
статья, добавлен 27.03.2016The role of genomic disorders of chromosome 17 in the region 17p13.1, where gene of malignant transformation TP53 is localized in substrate cells of bone marrow. The results of cytogenetic studies in patients with chronic lymphoproliferative neoplasms.
статья, добавлен 30.10.2016The antitumor immunity in patients with cancer of the oral cavity, oropharynx during treatment (chemoradio therapy), which additionally included immunotherapy with a/f-defensin. Dose-dependent decrease in the relative number of lymphocytes in the blood.
статья, добавлен 12.06.2022Identification of protective factors and development of prevention programs that will help reduce the risk of developing occupational burnout syndrome and cardiovascular diseases. The need to improve the quality of life of general practitioners.
статья, добавлен 16.01.2024