Molecular docking of ZSTK474 derivatives as potential PI3Kbeta inhibitory agents
Overexpression in many human cancers. Molecular docking of ZSTK474 derivatives as PI3Kbeta inhibitory agents. Review absorption, distribution, metabolism and excretion and possible pharmacological activity сhemical. Additional binding energy human.
Подобные документы
Investigation of variant formation ways additional chromosomal abnormalities in clones. Simultaneous existence in mosaic karyotypes clones with additional quantity, structural chromosomal twinning witness for multi steps models of the clone evolution.
статья, добавлен 18.12.2023Role of the lymphocytes. The undifferentiated cytotoxic Tlymphocytes’ premature migration from thymus to the peripheral organs. Review of dynamic of the lymphoid formations’ distribution of the rats’ major salivary glands after antenatal antigen action.
статья, добавлен 06.02.2017A comprehensive study of the pharmacological properties of soft drugs. Methods of regulation of drugs for the treatment of wounds. The stability gel when the temperature changes. Structural-mechanical and rheological characteristics of the product.
статья, добавлен 29.01.2016Study the effect of EMAP II, IFN- 2b and its medicinal preparations on the amount of O6-methylguanine-DNA methyltransferase (MGMT) protein in human cells in vitro. The effect of medicinal preparations. Changes in the methyltransferase gene expression.
статья, добавлен 29.01.2017The effect of a diazepinone on purine and lipid metabolism in liver of rats with Parkinson’s disease caused by rotenone by studying the composition of bile. Diazepinone improves the metabolism of purines and lipids in liver of rats with ROT-simulated PD.
статья, добавлен 05.06.2022Deterioration of hypobaric hypoxia with increasing height, which leads to stress of biological systems due to the lack of a constant, uninterrupted supply of oxygen to mitochondrial metabolism. Potential clinical utility of hypoxia preconditioning.
статья, добавлен 20.06.2020The pharmacological characteristics of the aerial parts of black Horehound. The structure and content of the therapeutic components in vegetative and generative parts of the Horehound. Formulation development of medications of the considered plants.
статья, добавлен 24.02.2016Familiarization with the results of studies on the effect of various concentrations of preservatives on the antimicrobial activity of medicinal syrup. Review and characterization of antimicrobial activity of investigated samples with preservatives.
статья, добавлен 26.01.2021Chemotherapy as one of the major tool in the treatment of breast cancer. The main etiology of the development of drug resistance of cancer cells to chemotherapeutic agents. Analysis of the effect of anticancer drugs on the cells of breast carcinoma.
статья, добавлен 27.03.2016The results of molecular cytogenetic studies in 60 patients with chronic lymphoproliferative neoplasms. Clonal deletions of TP 53 gene were detected in 20% of patients with CLPN: eight of 20 patients with B-cell chronic lymphocytic leukemia (B-CLL).
статья, добавлен 18.12.2023Analysis of the effects of 2 chemical retraction agents on gingival blood flow and systemic blood pressure in subjects with healthy gingival were investigated. investigation and assessment of the impact on blood flow gingival retraction gingival.
статья, добавлен 05.03.2013Investigation of development of synthetic methods and study of physicochemical and biological characteristics of hetarylcarboxylic acids. Characteristic of the results of the pharmacological research of (2-oxoindolin-3-ylidene)-2-oxoacetic acid.
статья, добавлен 24.02.2016Assessment of the results of clinical genealogical and molecular-genetic observation of patients with ovarian cancer. The rationale for its role as an important step for the creation of genetic risk groups for the development of neoplasia in the family.
статья, добавлен 01.12.2017Meaning of calcium hydroxide as intracanal medicament for antimicrobial activity. Physico-chemical properties of this substance and its efficacy for disinfecting the entire root canal system. The relationship of calcium hydroxide with medications.
статья, добавлен 29.03.2013Study of the problems of music therapy associated with dementia. Music therapy is a non-pharmacological approach for the treatment of patients with dementia. Use of musical instruments to improve communication between a music therapist and clients.
статья, добавлен 28.12.2017Photoreceptor cGMP phosphodiesterase is an effector enzyme in the G-protein mediated visual transduction cascade. To study the mechanism of PDE6 catalytic activity inhibition by Py chimeric proteins PDE6a/PDE5 were created. The catalytic properties.
статья, добавлен 19.03.2024Investigation of the role of metabolic disorders in the formation of disease among newborns. The study showed the clinical efficacy of the drug L-carnitine in the treatment of protein deficiency. The positive effect of "Agvantar" as metabolic therapy.
статья, добавлен 27.03.2016- 93. Biological active substances of natural origin and rheumatoid arthritis, prevention or treatment
Research on non-steroidal anti-inflammatory drugs, which are an option for the symptomatic treatment of rheumatoid arthritis. Disease-modifying antirheumatic drugs. The use of pharmacological treatment schemes in the early stages of the disease.
статья, добавлен 19.03.2024 The correlation analysis of evoked brain potential components and the indexes of highly genetically determined features of higher nervous activity. Possible neuro-physiological mechanisms with highly genetically determined neuro-dynamic properties.
статья, добавлен 29.09.2016The character of food, age of contact with the potential food allergens and development of food tolerance. Periods of pregnancy, neonatal period and type of feeding. Choosing of additional food without any recommendations, switch to artificial, mix food.
презентация, добавлен 22.11.2016Biochemical markers - component that provides information on the prognosis and course of pathology. Comparative analysis of the basic biochemical parameters that reflecting the metabolism of acute-phase proteins in a group of experimental animals.
статья, добавлен 05.06.2022The concept and description of early left ventricular anomalies, the problems of their diagnosis using standard echocardiography in patients with hypertension and impaired glucose metabolism. Study of changes in their function by echocardiography.
статья, добавлен 13.01.2017Understanding the nature of mood changes in people with Alzheimer's. Development of recommendations and planning appropriate pharmacological and non-pharmacological treatment. The depressive symptoms of patients with Alzheimer’s and vascular dementia.
статья, добавлен 14.08.2020Study the interaction of adaptor protein Ruk/CIN85 SH3 domains with endogenous indicator Tks4 in tumor cells of different tissue origins. Research of physiological responses of cell immunity in mice. New multiple molecular forms of adaptor protein.
статья, добавлен 27.03.2016Correction of redox metabolism based on the parameters of oxidative modification of proteins, the degree of their catabolic reaction and data on the lipid peroxidation in cancer patients with multiple organ resections on the gastrointestinal tract.
статья, добавлен 18.04.2022