Molecular docking of ZSTK474 derivatives as potential PI3Kbeta inhibitory agents
Overexpression in many human cancers. Molecular docking of ZSTK474 derivatives as PI3Kbeta inhibitory agents. Review absorption, distribution, metabolism and excretion and possible pharmacological activity сhemical. Additional binding energy human.
Подобные документы
Structural formula of Tedizolid as antimicrobial and structural analogue and proposed 5-phenyl-5,6-dihydrotetrazolo[1,5-c]quinazolines. Affinity to binding sites of 2QEX, with decreasing of score. Descriptives of formed bonds to 50S ribosomal protein L2P.
статья, добавлен 04.09.2024The search for new and effective antimicrobial and antifungal agents is an important task of medical chemistry. The results of microbiological screening of new derivatives of [1,2,4]triazolo[4,3-a]pyrazine. Increased exposure to the microbial cell.
статья, добавлен 27.10.2016Microscopic fungi including yeasts are important part of human microbiota. The molecular genetic identification of human sputum yeast isolate MF22_1, belonging to Candida spp., by using multiple genetic markers including ribosomal operon regions.
статья, добавлен 10.06.2023Genetic, cellular, tissue and circulating markers in Tumors. Diseased regulatory pathways. Growth Factor-Signaling Pathways in Cancer. Antitumor immunity as therapy for human cancer. Invasion and Metastasis. Emerging molecular therapies for the disease.
книга, добавлен 05.07.2013Pharmacological activity of the main derivatives of 1,5-benzodiazepines. Interaction of 4-phenyl- and 4-methyl-2,3-dihydro-1H-1,5-benzodiazepinones-2 with epichlorohydrin under various conditions. The use of hard and soft basic reaction systems.
статья, добавлен 30.10.2016Analysis of the problem of search biologically active substances among derivatives of aromatic aminoacids. Research of physical and chemical properties and structure, pharmacological activities of methyl esters of 6-nitro-N-phenylanthranilic acids.
статья, добавлен 24.02.2016Identification of the effect of kinetzitherapeutic agents and methods on improving the health status of patients with Down syndrome. Study of the features of the disease caused by the presence of an additional chromosome in the human genetic structure.
статья, добавлен 25.11.2021Pharmacokinetics of drug fate. The mechanism altering drugs absorption, distribution, metabolism. Identify drugs interactions, the mechanisms of older interactions, and examine the safety of new drugs from classes that are known to cause interactions.
статья, добавлен 10.12.2013JNK inhibitors in biomedical experiments. The study of the molecular mechanisms of development of damage and adaptation of cell systems at the pathological conditions of different genesis. The apoptosis and the imbalance of oxidative metabolism.
статья, добавлен 21.06.2016The first laboratory of systems biology in Ukraine. Study the response of primary hepatocytes to interferon. Development of a stoichiometric model of folate-related metabolism in human placenta. The system’s behavior at different human pathologies.
статья, добавлен 27.03.2016- 11. State of neurotransmitters (glutamate and gamma-aminobutyric acid) in patients with Wilson’s disease
Study inhibitory and excitatory neurotransmitters in patients with Wilson's disease. The contents in the blood serum of the neurotransmitter glutamate and the inhibitory neurotransmitter gamma-aminobutyric acid. Over-stimulation of the brain structures.
статья, добавлен 13.10.2016 The use of biochemical markers of connective tissue metabolism disorders in respiratory diseases in humans and animals. Diagnosis of chronic bronchitis and asthma in dogs and cats using cytokines (interleukin, interferon) and bronchoalveolar lavage.
статья, добавлен 25.04.2022Indications for the walking bleach technique. Bleaching agents for the whitening of root-filled teeth. Influence of bleaching agents used for the bleach technique on tooth tissue. Examination of root fillings, existing restorations and tooth substance.
статья, добавлен 29.03.2013- 14. Skeleton
The number of the bones in the adult human skeleton. Main functions of the skeleton. Sex-based differences between the male and female human skeletons. Neurocranium and viscerocranium components of the human scull. Picture of the human skeleton.
презентация, добавлен 25.12.2012 Atherosclerosis: Signal Transduction by Oxygen and Nitrogen Radicals. Apoptotic Pathways in Cancer Progression and Treatment. Molecular and Cellular Aspects of Insulin Resistance: Implications for Diabetes. Neurotrophic Signaling in Mood Disorders.
книга, добавлен 05.07.2013Microbiological and molecular methods used to study the microorganisms associated with endodontic infections. Endodontic infections are polymicrobial with usually from 3–12 species cultivable from either infected root canals or periradicular abscesses.
статья, добавлен 10.12.2013Small animal models of osteoarthritis are suitable for preclinical investigations of OA pathogenesis: its genetic and molecular mechanisms; large animal allow to investigate biomechanical changes of the joint and to provide intraarticular interventions.
статья, добавлен 30.07.2016The pharmacological effect of the Phytocomposition №1+PhytoF on the functional state of hepatocytes, metabolism of proteins in comparison with the classical hepatoprotector Essentiale. The role of ceruloplasminin of protein metabolism in the liver.
статья, добавлен 30.04.2018Synthetic, physical-chemical and pharmacological studies of amino-nitrophenyl-triazole-thiones. The research of high actoprotective, antioxidant, neuroprotective activity of this compоund. Practical substantiation of its application as a potential drug.
статья, добавлен 26.07.2016The influence of dentin on the effectiveness of three antibacterial agents (triclosan, glutaraldehyde, NaOCl) on Streptococcus mutans, Streptococcus sobrinus, and Lactobacillus acidophilus. The agar diffusion method with and without bovine dentin discs.
статья, добавлен 29.03.2013The role of immune cells in protecting the human body from pathogens and viruses. The influence of biologically active nutrients and bioactive substances in enhancing human innate and adaptive immunity for the prevention of COVID-19 in the population.
статья, добавлен 24.02.2024Non-adjuvant polychemotherapy - technology that indicates the presence of chemo-resistant tumor cells. Molecular-biological markers of tumors - certain chromosomal and gene mutations that involved in the development, progression of malignant diseases.
статья, добавлен 11.08.2021Production of active human interferon alfa 2b in plants of Nicotiana excelsior, previously selected as a promising host species for agrobacterium mediated transient expression using GFP marker protein. Activity of interferon in leaf extracts of N.
статья, добавлен 16.11.2012Bradykinin receptor 2 as an attractive therapeutic agent for glioma patients. A high antiproliferative activity in the human glioblastoma cells U373. Effect of nonapeptide bradykinin antagonists on U373. BKM-570 as a potential anti-cancer agent.
статья, добавлен 27.03.2016The chromosomal anomalies, microdeletions of AZF region of Y-chromosome and CFTR gene mutations. Genetic factor of infertility and Y-chromosome AZF region microdeletions of males with spermatogenetic failure. The frequency of CFTR major mutation F508del.
статья, добавлен 24.11.2012