Synthesis and antiviral activity of [(9-R1-10-R2-3-R-2-OXO-2H-[1,2,4]-triazino[2,3-c]quinazolin-6-YL)thio] acetamides derivatives with the fragments of carcass amines
Alkylation of potassium 9-R1-10-R2-3-R-2-oxo-2Н-[1,2,4]triazino[2,3-с]quinazolin-6-thiolates by N-cycloalkyl-(cycloalkylaryl-)-2-chloracetamides. Analizes of indicators of the antiviral activity of compounds 3.2 and 3.14 against influenza type A H3N2.
Подобные документы
Prepared of n-aryl-2-[(4-amino-4H-1,2,4-triazol-3yl)thio] acetamides by interaction of amino-1,2,4-triazolyl-3thiol with n-aril-2-chloroacetamides and formation of n-aryl-2-[6,8-dimethyl[1,2,4]triazolo[4,3-b]pyradazin-3-yl)thio]acetamide derivatives.
статья, добавлен 18.02.2014The study of the synthesis and physicochemical properties of derivatives of 4-phenyl-5-(1,2,3-benzotriazolyl 1)-3-merkapto-1,2,4-triazole(4H). Due to computer prognosis data the substances synthesized are prospective anticonvulsants and antiasthmatics.
статья, добавлен 05.03.2014Drugs based on the 1,2,4-triazole have a wide spectrum of biological activities. They are effective cardioprotectors, hepatoprotectors, anti-oxidants. Compounds with strong diuretic activity have been found among the newly synthesized compounds.
статья, добавлен 13.01.2017Convenient method of synthesis of optically active oxamoylaminoacids. Compounds have significant hepatoprotective, antiinflammatory and immunodepressant activities with low toxicity. Influence of investigated sudstances on rarametrs of specific immunity.
статья, добавлен 15.02.2014Method of syntesis of novel N-substituted 3-(aminosulfonyl)-2H-1-benzopyran-2-one in the Knoevenagel condensation conditions. Studing the biological activity of derivatives against protozoan and helminth parasites, active against Onchocerca lienalis.
статья, добавлен 19.02.2014Testing scheme of the synthesis of ester atsalamov acids and subsequent cyclization of the intermediate 3-hydrazinopyridazine-2-ones with carbonyl-containing compounds to provide chemical diversity of the final products containing a practical substitute.
статья, добавлен 20.03.2016- 7. A synthetic approach of d-glucose derivatives: spectral characterization and antimicrobial studies
Synthesis of new series of derivatives of methyl 4, 6-o-(4-methoxybenzylidene)-b-D-glucopyranoside direct acylation with a wide range of acylating agents. Spectral and elemental analysis data of antibacterial action of the synthesized compounds.
статья, добавлен 23.02.2016 The method of synthesis of fluorinated heterocycles. The use of mono- and 1,3-dicarbonyl substrates and their nitrogen-containing analogues. Biological activity, physical and chemical properties of heterocyclic compounds with perfluoroalkyl groups.
научная работа, добавлен 05.03.2013Purines Fused to Six-Membered Heterocycles. Pyrido-, pyridazino-, pyrimido-, pyrazino-, oxazino-, thiazino-, triazino-purines. Purines Fused to Seven- and Eight-Membered Heterocycles. Oxdiazocino- and Thiadiazocino-Purines Efforts to obtain compounds.
статья, добавлен 05.03.2013Application of the SwissADME web tool for the analysis of pharmacokinetics and properties of medicines. Study of antimicrobial activity and toxicity of phenylquinazoline derivatives, Assessment of metabolism, determination of solubility of compounds.
статья, добавлен 03.09.2024Using phosphoric acid and phosphor pent oxide as new catalyst for preparing of derivatives of benzoxazole. Use of benzoaxol ring in medicinal chemistry. Synthesis of 1,3-(Benzene-1,3-diyl) bis(benzoxazole). Synthesis of 3-(2-Hydroxynaphthol) benzoxazole.
статья, добавлен 21.01.2021The efficient synthetic protocol for aminomethylation proceeding was developed which led to obtaining a series of novel 3-(phenylamino)-methyl derivatives of 5,7-dimethyl-6-phenylazo-3Н-thiazolopyridin-2-one. The conditions for aminomethylation reaction.
статья, добавлен 30.08.2016Determination of biological activity of newly synthesized physiologically active substances. Study of antimicrobial activity, inhibits the development of gram-positive and gram-negative microorganisms. The features of systematic studies of 4-ticinonline.
статья, добавлен 28.01.2017- 14. Synthesis and crystal structure of an Ag(I) complex of composition (C9H7N(C3H5))2[AgBr2]Br(H2O)2
Coordination behavior of Ag (I) with cations of N-allyl quinolinium. Synthesis of N-allyl quinolinium bromide. Determination of the structure of the x-ray crystal. Bromine ions of the second crystallographic type. Study silver nitrate compounds.
статья, добавлен 23.02.2017 Synthesis of folate-ferrocene conjugate (FFC) through a stage of synthesis ferrocene carboxylic acid. Confirmation of the structure of the conjugate by the methods of spectroscopy. Studies of the biological activity of FFC by the method of tissue culture.
статья, добавлен 21.12.2016The ultrasonic cavitation activity in aqueous solution of carbon dioxide was studied. The ICA-3M cavitometer was used for cavitation activity estimation. Erosion rate was estimated in a number of regimes. The spectra of cavitation noise were recorded.
статья, добавлен 19.02.2021History of the free element. Isotopes, properties: physical, chemical. Potassium cations in the body. Biochemical function, membrane polarization. Filtration, excretion, potassium in the diet and by supplement. Applications: biological, food, industrial.
реферат, добавлен 13.11.2009Influence of increasing the temperature of thermochemical activation of up to 750 °C and increasing the dosage of potassium hydroxide to 2.1 g/g of activated carbon synthesis of hydrolytic lignin on the formation of adsorption properties of the AC.
статья, добавлен 30.07.2017Applications heterocyclic compounds; approaches to synthesis. Familiarization with effective conversion of organic compounds into valuable fluorinated products. The use of fluorinated triazoles for the protection of metals and alloys from corrosion.
научная работа, добавлен 05.03.20133-Bromo and 3-chloro-3-trifluoroacetyl-1-methyl-2-pyrrolidinones by the halogenation reaction of the corresponding 3-trifluoroacetyl derivatives. Characteristic hydrates after simple filtration on silica gel. The formation of new spirocyclic lactams.
статья, добавлен 14.02.2014The basic properties of alkoxides. Production technology of alkali metals alkoxides. Direct Synthesis in the Interaction of Metal and Alcohol. Interaction Metals Oxides and Hydroxides with Alcohols. Exchange reactions with alcohols, transesterification.
статья, добавлен 28.07.2017Synthesis of two rare-earth nickel silicide PrNi9Si4 and NdNi9Si4. Their crystal structures, refined from X-ray powder diffraction data, structure type. The two compounds as Curie-Weiss paramagnets due to magnetic moments carried on the rare-earth atoms.
статья, добавлен 23.02.2017Consideration of the results of x-ray diffraction of the considered chemical compounds. Structural properties of the films of magnesium oxide. Substantiation of optimum parameters of temperature of synthesis of organic and many inorganic compounds.
статья, добавлен 30.07.2016Chemical properties of organic compounds derived from ammonia. The mechanism of substitution of hydrogen for hydrocarbon radicals within molecules. Classification of the most common amines. Familiarization with the formula for the secondary amine.
презентация, добавлен 06.12.2016Biological, physical and chemical properties of macrocyclic compounds based on the researches of membrane activity. Finding of the certain concentration of filipin for increase of conductivity, definition of selectivity and single ionic filipin channels.
статья, добавлен 22.02.2021