Calix[4]arene alfa-hydroxymethylphosphonic acids as potential inhibitors of protein tyrosyne phosphatases
The combination of a macrocyclic platform and alfa-hydroxymethylphosphonate group for the inhibition activities of compounds. Computer-simulated docking studies using AutoDock 4.2 programme by the example of PTP1B. Stereoisomeric forms of the inhibitors.
Подобные документы
Study of ternary intermetallic compounds RxMyXz (R = rareearth Element, M = d-metal, X = p-metal). Results of identification of the new R-Au-Al compound. The starting materials for the synthesis of R-Au-Ga. Function of the profile form of pseudo-Voigt.
статья, добавлен 23.02.2017Critical reviews on "Heterocyclic Compounds" within topic-related volumes dealing with all aspects such as synthesis, reaction mechanisms, structure complexity, reactivity, stability, biology, pharmacological aspects, applications in material sciences.
учебное пособие, добавлен 05.03.2013Catalytic, electrical, optical and magnetic properties of cobalt sulfide. Chemical structure and application of inorganic compounds and salts the sulfurous acid. Brief description of the structure of pyrite. Methods for the synthesis of the metals.
статья, добавлен 30.07.2016Application of the SwissADME web tool for the analysis of pharmacokinetics and properties of medicines. Study of antimicrobial activity and toxicity of phenylquinazoline derivatives, Assessment of metabolism, determination of solubility of compounds.
статья, добавлен 03.09.2024Research modifications in the process of protective coating forming while heating. Examination of interaction between silicium organic compounds based on the rich polymethylphenylsiloxane. Opportunities of their utilization for high-temperature.
статья, добавлен 24.02.2016MPWB1K/6-31+G(d) and MPWB1K/tzvp theoretical models were found to provide reasonable accuracy of the prediction of ionization potentials for mono- and polycyclic azacompounds. The root mean square errors of the methods are 0.19 and 0.20, respectively.
статья, добавлен 30.10.2016Mechanistic aspects of the Diels-Alder reaction. The effect of micelles on it. The effects of Lewis acids on the endo-exo selectivity in water compared to the effects in organic solvents. Enantioselective cid catalysis of an organic reaction in water.
книга, добавлен 05.03.2013Anodic deposition of own and extrinsic hydroxides on aluminium from electrolyte was studied by voltastatic method at low and high voltages. The mechanism of precipitation using the conception of fast neutralization coagulation, the models of nucleation.
статья, добавлен 27.07.2016Benzisothiazolium Salts. Heterocyclic Annulated Isothiazolium Salts. Structure. X-ray Diffraction. Molecular Spectra. Analytical methods. Reactivity, general survey. Oxidation to Sultims and Sultams. Ring Transformation in Other Heterocyclic Compounds.
статья, добавлен 05.03.2013Silicides of rare earth metals. Crystallographic data for a binary compound in Pr-Si and Zr-Si systems. Study of the structure of the binary compound Zr3Si2. Analytical correction of absorption. Displacement parameters and interatomic distances.
статья, добавлен 23.02.2017The X-ray diffraction study of the isotypic structures of I and II reveals that the crystal structure consists of three structural units. The coordination polyhedron of the lanthanide atom. Atomic coordinates and equivalent displacement parameters.
статья, добавлен 23.02.2017Advances in heterocyclic chemistry. Molecular cascade and the formation of heterocyclic compounds and their impact on cost and waste reduction in the use of natural resources for production, the impact on the environment, energy and resource conservation.
научная работа, добавлен 05.03.2013Alkylation of potassium 9-R1-10-R2-3-R-2-oxo-2Н-[1,2,4]triazino[2,3-с]quinazolin-6-thiolates by N-cycloalkyl-(cycloalkylaryl-)-2-chloracetamides. Analizes of indicators of the antiviral activity of compounds 3.2 and 3.14 against influenza type A H3N2.
статья, добавлен 29.01.2016Film materials with ion-exchange properties based on polymer obtained by condensation of oligoepichlorohydrin epoxide and piperazine with chemical modification. Compounds that have different thermodynamic affinities with the polymer and with each other.
статья, добавлен 30.10.2016Magnesium as a chemical element and a silvery-white, light-weight metal. Notable characteristics, applications. As the metal. Incendiary use, in magnesium compounds. History, sources, ores, sea water, electrolysis. Biological role, isotopes, precautions.
реферат, добавлен 13.11.2009Synthesis ferroelectric compounds Sr(B1/3Nb2/3)O3 by solid state reaction technique. Consideration of the correlation between the dielectric response and transport behavior. Emprovement dielectric material properties. Motion energy storage devices.
статья, добавлен 30.07.2016Analysis of the results of the design and selection of compounds antimicrobial ointments containing gentamicin as the main active ingredient gallotannin and succinyl as a component of antiresistant against multiresistant strain of Pseudomonas aeruginosa.
статья, добавлен 29.10.2016- 68. Synthesis and crystal structure of an Ag(I) complex of composition (C9H7N(C3H5))2[AgBr2]Br(H2O)2
Coordination behavior of Ag (I) with cations of N-allyl quinolinium. Synthesis of N-allyl quinolinium bromide. Determination of the structure of the x-ray crystal. Bromine ions of the second crystallographic type. Study silver nitrate compounds.
статья, добавлен 23.02.2017 Purines Fused to Six-Membered Heterocycles. Pyrido-, pyridazino-, pyrimido-, pyrazino-, oxazino-, thiazino-, triazino-purines. Purines Fused to Seven- and Eight-Membered Heterocycles. Oxdiazocino- and Thiadiazocino-Purines Efforts to obtain compounds.
статья, добавлен 05.03.2013Purines fused with five-membered heterocycles: pyrrolo-, oxazolo-, thiazolo-, imidazo-, pyrazolo-, triazolo- and tetrazolo-purines. Purines annulated with five-membered rings. Compounds with a greater selective efficacy without the unwanted side-effects.
статья, добавлен 05.03.2013Identification techniques of fluacizine by color reactions and thin layer chromatography. The results of chromatographic analysis of fluacizine for two systems of solvents. The fluacizine detection by UV-spectrophotometry in phosphate buffer solution.
статья, добавлен 25.03.2016History of the nucleophilic substitution of hydrogen in aromatic compounds, obtaining picric acid. Survey of SNH Substitution. Heterocyclizations Based on SNH Reactions. Intramolecular One-Step SNH Cyclizations; cascade Sequences Based on SNH Reactions.
научная работа, добавлен 05.03.2013Reductive opening of heterocycles as a source of functionalized organolithium compounds. Methods for homologation of heterocycles. Double lithiation of thianthrene. Phthalan: a versatile starting material. Homologation of six-membered heterocycles.
статья, добавлен 05.03.2013Oxidized with solution of hydrogen peroxide multiwalled carbon nanotubes (MWCNTs) were modified with 2-hydroxyethylmethacrylate (HEMA) or chitosan (CTS). Morphology and surface properties of the pristine and modified MWCNTs have been investigated.
статья, добавлен 03.04.2014The complexation of 3-alkylcarbonyloxy-7-dihydro-3Н-1,4-benzodiazepine with the central benzodiazepine receptors at six temperatures. The ester carbonyl groups in compounds 1 and 2 are also supposed to form different hydrogen bonds with the receptor.
статья, добавлен 05.03.2014