Calix[4]arene alfa-hydroxymethylphosphonic acids as potential inhibitors of protein tyrosyne phosphatases
The combination of a macrocyclic platform and alfa-hydroxymethylphosphonate group for the inhibition activities of compounds. Computer-simulated docking studies using AutoDock 4.2 programme by the example of PTP1B. Stereoisomeric forms of the inhibitors.
Подобные документы
Elucidation of the mechanisms of bioaccumulation of copper, leached from minerals with the help of the fungus aspergillus Niger with a large bioremedial potential due to its ability to produce chelating metabolites and transformation of toxic minerals.
статья, добавлен 19.02.2016Chemical compositions of Portland cement. Possibility of using waste glass in building technology. A structure alkaline compounds. Study of fine-grinded glass. Influence additives on the induction and post-induction periods of Portland cement hardening.
статья, добавлен 23.02.2016Effect of polymerization copolymers on selenophenes and thiophenes. Analysis of electrosynthesis of selenofen-thiophene copolymers at a constant electrode potential. Stability of oxidation-reduction activity in electrolyte solution based on acetonitrile.
статья, добавлен 30.08.2016Natural zeolite clinoptoline and its nanomodified forms have been used for modification of structures of the composite building materials. Characteristics of this zeolite have been studied by thermal analysis, IR spectroscopy, and adsorption methods.
автореферат, добавлен 02.04.2014The mechanism of binding of Cr(acac)3 molecules at active sites of the surface of silica and alumina supports. Silica support due to hydrogen bonding with acetylacetonate ligand. Interaction of p-electrons of acetylacetonate ligands with Al3+ sites.
статья, добавлен 19.03.2014Synthesis of folate-ferrocene conjugate (FFC) through a stage of synthesis ferrocene carboxylic acid. Confirmation of the structure of the conjugate by the methods of spectroscopy. Studies of the biological activity of FFC by the method of tissue culture.
статья, добавлен 21.12.2016Physicochemical characterisation of casein micelles suspended in milk ultrafiltrate and enriched with different cations: Fe, Cu, Ca. The order of association of cations with casein micelles. Changes in hydrophobicity, zeta potential of casein micelles.
статья, добавлен 20.11.2013Systematic studies on the preparation of sodium silicate solutions of different compositions via the hydrothermal microwave treatment of perlite with an NaOH solution. The effect of various factors on the degree of SiO2 recovery and the reaction rate.
статья, добавлен 07.01.2017On the basis of experimental studies and mathematical modeling, the choice of optimal conditions for 2,3-dimethylbuta-1,3-diene and 2-hydroxyethyl methacrylate cyclization reaction with obtaining of 2-hydroxyethyl-1,3,4-trimethylcyclohex-3-carboxylates.
статья, добавлен 23.02.2016Experimental studies and calculations comparing the hierarchical structures at two zoom levels – nanometer and micrometer. The features of multiscaling and hierarchy in zirconium alloys. Data about the hierarchical structures of the multiscale chain.
статья, добавлен 27.07.2016Conducting a study of the activities of the assay and analytical laboratory to determine the gold content in gold-containing products. Atomic absorption, tetrometric and assay-gravimetric analysis methods for determining the gold content in products.
статья, добавлен 31.08.2020