Molecular docking of 5-phenyl-5,6- dihydrotetrazolo-[1,5-C]quinazolines to ribosomal 50S protein l2P (2qex)
Given the presence of antimicrobial activity for tetrazole derivatives and its condensed analogues, it was proposed to analyze 13 novel 5-phenyl-5,6-dihydrotetrazolo[1,5- c]quinazolines for molecular docking to ribosomal in comparison with Tedizolid.
Подобные документы
Search for the main approaches to the individualization of adjuvant chemotherapeutic treatment of breast cancer. The peculiarity of the study of the effectiveness of anthracycline chemotherapy regimens for various molecular biological tumor subtypes.
статья, добавлен 23.02.2021Determination of the number of matrix ribonucleic acid genes in leukocytes in some forms of epilepsy and Parkinson's disease. Identification of new biomarkers of diseases for the development of molecular test systems suitable for clinical diagnosis.
статья, добавлен 19.04.2018The problem of resistance of atypical endometrial hyperplasia to traditionally accepted, pathogenetically justified therapy with various types of progestins remains. The aim of the study was to review the literature sources to clarify the reasons.
статья, добавлен 20.03.2024The main stages of the recovery process integrity of bone in the case of instability of bone fragments and a significant distance between them. Factors affecting proliferation, differentiation of osteogenic cells, synthesis of extracellular matrix.
статья, добавлен 27.12.2016- 30. Tuberculoma
The presence in the lungs rounded and limited size of the focus fabric 2 cm or more. Classification tuberculoma, which was proposed by M.M. Averbakh. Tuberculoma of infiltrative-pneumonic type. Laboratory investigation and differential diagnostics.
презентация, добавлен 24.03.2016 Evaluation of the clinical contribution of vitamin K deficiency protein in the diagnosis of hepatocellular carcinoma. Comparison of PIVKA-II with the AFP used for the same indication. Evaluation of the effectiveness of the combined use of both biomarkers.
статья, добавлен 02.06.2021Issues of differential diagnostics, treatment of endometrial hyperplasia in women of reproductive age using various types of progestins. Study of the algorithm for predicting the effectiveness and review of the causes of resistance to progestin therapy.
статья, добавлен 19.09.2024The results of molecular cytogenetic studies in 60 patients with chronic lymphoproliferative neoplasms. Clonal deletions of TP 53 gene were detected in 20% of patients with CLPN: eight of 20 patients with B-cell chronic lymphocytic leukemia (B-CLL).
статья, добавлен 18.12.2023Assessment of the results of clinical genealogical and molecular-genetic observation of patients with ovarian cancer. The rationale for its role as an important step for the creation of genetic risk groups for the development of neoplasia in the family.
статья, добавлен 01.12.2017Photoreceptor cGMP phosphodiesterase is an effector enzyme in the G-protein mediated visual transduction cascade. To study the mechanism of PDE6 catalytic activity inhibition by Py chimeric proteins PDE6a/PDE5 were created. The catalytic properties.
статья, добавлен 19.03.2024Peculiarities of the course of transmissible spongiform encephalopathies depending on the patterns of protein structure formation and their interaction with cell membranes. The mechanism of formation of the pathogenic isoform of the prion protein.
статья, добавлен 20.09.2024Protein degradation plays a key role in many cellular processes, degrading misfolded or abnormal proteins and thereby controlling cell proliferation, DNA repair, and stress response. Primers creating and design. Phylogenetic comparative analysis.
статья, добавлен 10.10.2024- 38. Justification of composition and technology of granules with sunflower protein and plant polyextract
Development of new dosage forms for immunomodulatory and antitussive drugs created based on natural compounds: polyextract of ntitussive and sunflower vegetable protein. The study obtained the drug granulate in accordance with a new method of SPhU.
статья, добавлен 29.11.2016 Study the effect of EMAP II, IFN- 2b and its medicinal preparations on the amount of O6-methylguanine-DNA methyltransferase (MGMT) protein in human cells in vitro. The effect of medicinal preparations. Changes in the methyltransferase gene expression.
статья, добавлен 29.01.2017A modern alternative approach to antimicrobial therapy is targeting bacterial virulence and specifically adhesion as one of virulence factors. Modern strategies for anti-adhesion therapy, the mechanisms of inhibition pathogen adherence, immunization.
статья, добавлен 19.03.2016Study of the content of fatty acid-binding protein in the blood serum of patients, total cholesterol, high-density lipoprotein and triglyceride content. Calculation of the coefficient of atherogenicity, the level of very low, low-density lipoproteins.
статья, добавлен 28.02.2023Protective and therapeutic effects of the associated inactivated suspension of C. albicans and C. tropicalis fungi and the associated antigens of C. albicans fungi with the protein. Compare protective and therapeutic properties of associated antigens.
статья, добавлен 26.07.2016Analysis of the problem of search biologically active substances among derivatives of aromatic aminoacids. Research of physical and chemical properties and structure, pharmacological activities of methyl esters of 6-nitro-N-phenylanthranilic acids.
статья, добавлен 24.02.2016Assignment of Disulfide Bonds in Proteins by Chemical Cleavage and Peptide Mapping by Mass Spectrometry. Enzymatic Sequence Analysis of N-Glycans. Analysis of S-Acylation of Proteins. Identification Protein Phosphorylation Sites with Mass Spectrometry.
учебное пособие, добавлен 05.07.2013Neuroborreliosis constitutes a neurological sequelae of Lyme disease, due to the pathogenic activity of the spirochetal agent, Borrelia burgdorferi. The persistent intracellular presence of Borrelia gives rise to a primary cutaneous manifestation.
статья, добавлен 15.09.2024The relevance of sport includes all physical activity forms, in the context of which the self research and improving physical and mental health, aimed at curbing instincts. To do this, you should play sports and develop all physical activity kinds.
статья, добавлен 28.07.2023Study changes in TDS and protein oxidative modification measures in the brain of rats with experimental diabetes mellitus when using cerebroprotectors. Activity of glutathione reductase (GR) and glutathione peroxidase (GP) in the DM rat brain tissue.
статья, добавлен 13.08.2016In vitro antiproliferative activity. Cell Culture conditions. In vitro determination of antioxidant activity. The cytotoxic activity of these compounds against normal cells. Identification of side effects in other biosystems and animal experiments.
статья, добавлен 17.04.2018Causes of interappointment pain. Presence of pathogenic bacteria. Presence of virulent clonal types. Microbial synergism or additism. Number of microbial cells. Apical extrusion of debris. Secondary intraradicular infections. Non-microbial causes.
статья, добавлен 10.12.2013Dynamic assessment and determination of cell proliferative activity in tissues with low proliferative activity to its cumulative effect. Enzyme-linked immunosorbent assay and immunohistochemical study of chain reaction polymerization bromosuccinimide.
статья, добавлен 20.02.2016