Molecular docking of 5-phenyl-5,6- dihydrotetrazolo-[1,5-C]quinazolines to ribosomal 50S protein l2P (2qex)
Given the presence of antimicrobial activity for tetrazole derivatives and its condensed analogues, it was proposed to analyze 13 novel 5-phenyl-5,6-dihydrotetrazolo[1,5- c]quinazolines for molecular docking to ribosomal in comparison with Tedizolid.
Подобные документы
Bradykinin receptor 2 as an attractive therapeutic agent for glioma patients. A high antiproliferative activity in the human glioblastoma cells U373. Effect of nonapeptide bradykinin antagonists on U373. BKM-570 as a potential anti-cancer agent.
статья, добавлен 27.03.2016Most Enterococcus species and their habitat. A scanning electron micrograph of a dividing cell. Virulence and pathogenicity of enterococci. Modulation of the host immune response. Antimicrobial resistance of enterococci. E. faecalis and biofilm formation.
статья, добавлен 10.12.2013The leading role in addressing public health belongs to physical therapy specialists, the purpose of professional activity of which is the comprehensive restoration of the functional state of the person by means of physical and health technologies.
статья, добавлен 29.05.2022Study of the effect of Chloramine-T disinfectant at a dose of 9 mg / l in trout. Study of the toxic effects of Chloramine-T in relation to biochemical parameters in trout tissues. Aldehyde and ketone derivatives of oxidatively modified proteins.
статья, добавлен 25.02.2020The relevance of studying the triggering mechanisms of cervical carcinogenesis is due to the high frequency of human papillomavirus infection among young women. The effect of folate on DNA methylation and expression of the tumor suppressor FHIT protein.
статья, добавлен 15.11.2018The article examines the influence of living mesenchymal stem cells (MSCs) and biologically active substances secreted by them (exometabolites, or secretions) on bacterial cells and their colonies, as well as on immunocompetent cells of the host's body.
статья, добавлен 15.09.2024Working memory as a cognitive and neural phenomenon is characterized by a short-term dynamic storage of information. Models of working memory, cortical activity and rhythmic brain activity. Non-invasive brain stimulation in the study of working memory.
дипломная работа, добавлен 27.08.2018- 83. Different permutation entropy patterns of electroencephalogram recorded during epileptiform activity
Behavior of permutation entropy for the orders from 3 to 7 was shown for the electroencephalogram containing epileptiform activity. Time-entropy dependence for EEG with permutation entropy immediate increase after seizure onset for different orders.
статья, добавлен 26.06.2016 Using global liquid chromatography-mass spectrometry (LC-MS) – based proteomics, identified 24 serum proteins that were significantly variant between those with type 1 diabetes (T1D) and healthy controls. Development of multiplexed peptide assays.
статья, добавлен 02.09.2013Antibacterial efficacy of ethanol extracts from Ficus vasta Forssk against Aeromonas strains. The balance of benefits / risks of their use in the treatment of Aeromonas-induced aquaculture infections. Compounds responsible for the activity of the extract.
статья, добавлен 04.03.2020Analysis of the relationship of traditional risk factors for cardiovascular diseases with the activity of the inflammatory process and atherosclerosis in patients with psoriatic arthritis. Clinical characteristics of patients included in the study.
статья, добавлен 23.02.2021The sensitivity of nerve function to the action of various factors: from pharmacological to environmental pollutants. Part of neurospecific proteins in the processes of learning and memory. The level of lipid peroxidation after effect of melatonin.
статья, добавлен 14.08.2016Risk assessment and factors that can negatively influence the consumers’ health. The implementation of norms and standards of new antimicrobial medicinal product registration in the Ukraine. Antibiotic resistantce as risk assessment component for human.
статья, добавлен 26.01.2017Strategy of the search and working out of novel effective anticancer agents via optimization of [(2-R-quinazoline-4-ylydene) hydrazono] carboxylic acids and their esters. Approach for creating a new class of compounds with the anticancer activity.
статья, добавлен 30.10.2016Acquaintance with the main causes of the incidence of multiple sclerosis, consideration of diagnostic methods. Multiple sclerosis as a chronic progressive disease by the central nervous system, which primarily affects people of young and middle age.
статья, добавлен 17.04.2018Chlorhexidine gluconate is an effective oral antimicrobial agent and is used in periodontal therapy and for caries prevention. Mean leakage trends across time for each irrigant (sealer) combination. Effect of Chlorhexidine Gluconate on the Apical Seal.
статья, добавлен 30.03.2013Influence of the goutweed in the kidney and liver histological structure in mice with alloxan diabetes. Opposition to the development of necrosis and infiltration of protein renal tubules of mice after the administration of the infusion "Arfazetin".
статья, добавлен 24.02.2016The use of dosed physical activity in the rehabilitation program for patients with mild persistent bronchial asthma. Trial of the program of physical rehabilitation of patients taking into account the results of the examination of the functional state.
статья, добавлен 27.10.2020The etiology and pathogenesis of age-related macular degeneration. The risk factors for retinal edema. The value of the functional activity of platelet receptors for the occurrence of exudative hemorrhagic form of age-related macular degeneration.
статья, добавлен 22.02.2021The concept of a fibrous-elastic eye framework is proposed, including the Descemet's membrane, Dua's membrane, trabecular tissue, Bruch's membrane and the posterior border plate of the optic disc. Pathological processes with structures are described.
статья, добавлен 22.02.2023Consideration and evaluation of leukocyte and its populations count, leukocytes indices and plasma level of high sensitive C-reactive protein (hsCPR) in patients hospitalized due to acute coronary syndromewith or without of 2 type diabetes mellitus.
статья, добавлен 27.09.2022Identification of the effect of kinetzitherapeutic agents and methods on improving the health status of patients with Down syndrome. Study of the features of the disease caused by the presence of an additional chromosome in the human genetic structure.
статья, добавлен 25.11.2021The anthropomorphological examination of patients with Wilson’s disease. Studying the appropriate composition of this population and peculiarities of its structure. The association between this presence of pathology and Mediterranean phenotypic variant.
статья, добавлен 22.01.2017Effect of piracetam and interleukin- 1 receptor antagonist on the values of thiol-disulfide system and protein oxidative modification (POM) was studied based on the rat alloxan diabetes model. The reasons of damage to brain tissue of the animals.
статья, добавлен 13.08.2016The study of the level of physical activity, dairy products and calcium intake by students of Islamic Azad University of Damavand in Iran. Factors affecting the health of the skeletal system. Modern methods of preventing osteoporosis in female students.
статья, добавлен 05.12.2018